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human hcc organoid culture kit  (MedChemExpress)


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    MedChemExpress human hcc organoid culture kit
    Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in <t>HCC</t> organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived <t>HCC</t> <t>SNU-423-CO</t> organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.
    Human Hcc Organoid Culture Kit, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human hcc organoid culture kit/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    human hcc organoid culture kit - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma"

    Article Title: Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma

    Journal: International Journal of Biological Sciences

    doi: 10.7150/ijbs.118753

    Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in HCC organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived HCC SNU-423-CO organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.
    Figure Legend Snippet: Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in HCC organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived HCC SNU-423-CO organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.

    Techniques Used: Expressing, Gene Expression, MANN-WHITNEY, Derivative Assay, Microscopy



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    human hcc organoid culture kit  (MedChemExpress)
    94
    MedChemExpress human hcc organoid culture kit
    Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in <t>HCC</t> organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived <t>HCC</t> <t>SNU-423-CO</t> organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.
    Human Hcc Organoid Culture Kit, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human hcc organoid culture kit/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    human hcc organoid culture kit - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in HCC organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived HCC SNU-423-CO organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.

    Journal: International Journal of Biological Sciences

    Article Title: Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma

    doi: 10.7150/ijbs.118753

    Figure Lengend Snippet: Clinical relevance of SMOX , CERS1 , and SPHK1 expression and combining effects of sorafenib with spermine or sphingosine in HCC organoids. (A-B) The overall survival rates of liver cancer patients in TCGA were plotted according to the expression levels of the SMOX metabolic enzyme of spermine (A) and the CERS1 and SPHK1 metabolic enzymes of sphingosine (B) using KM Plotter. (C-D) The relative gene expression of SMOX (C) and SPHK1 (D) in normal (left) and tumor (right) tissues from adrenal cancer (Adrenal), acute myeloid leukemia (AML), bladder cancer (Bladder), breast cancer (Breast), colon cancer (Colon), esophageal cancer (Esoph), liver cancer (Liver), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSQ), ovary cancer (Ovary), pancreatic cancer (Pancreas), prostate cancer (Prostate), rectal cancer (Rectum), renal clear cell cancer (RCC), renal CH (RCH), renal PA (RPA), skin cancer (Skin), stomach cancer (Stomach), testis cancer (Testis), thyroid cancer (Thyroid), uterine CS cancer (UCS), and uterine EC (UEC). *: Mann-Whitney p<0.05 and expression >10 in tumor or normal tissue. (E-F) Patient-derived HCC SNU-423-CO organoids were treated with sorafenib with and without spermine or sphingosine for 6 days. (E) Representative images were obtained using a confocal microscope (TS100, Nikon, Tokyo, Japan). Scale bar, 50 μm. ( F ) Organoid formation efficiency and cell viability were assessed by CellTiter-Glo 3D assay. The relative organoid cell viability was plotted. Data are presented as the mean ± SD. ** p < 0.01; *** p < 0.001.

    Article Snippet: Patient-derived HCC SNU-423-CO organoids were obtained from KCLB (Seoul, Korea) and maintained using the human HCC organoid culture kit (Med Chem Express, Princeton, NJ, USA), supplemented with 50 ng/ml EGF, 100 ng/ml FGF, 25 ng/ml HGF, 10 mM forskolin, 1 × B27, 10 mM nicotinamide, 5 mM A83-01, 1.25 mM N-acetylcysteine, and 50 mg/ml primocin .

    Techniques: Expressing, Gene Expression, MANN-WHITNEY, Derivative Assay, Microscopy